The debate comes as U.S. Vaccination guidance has grown increasingly divided over the past year, with federal officials and doctors' organizations clashing over recommendations and even facing off in court. Despite that split, both sides are separately reviewing the longstanding HPV vaccine schedule, which for years has called for two shots in adolescents.

Jason Schwartz, a vaccine policy researcher at Yale University, called the potential change significant. "This would be a shift in terms of what has been communicated for many years about the best way to protect adolescents against HPV," he told the AP.

For parents and preteens, the stakes are real. HPV vaccines protect against a virus linked to several cancers. A single-dose schedule could simplify things for families and doctors, cutting down on missed appointments and follow-up visits.

Any change to HPV recommendations will land in an environment where doctors and health officials already disagree, and where the public has reason to wonder which experts to trust.

The number of shots needed to prevent cancer might be about to get cut in half, and nobody agrees on much else.