His statement comes after the party conference break. He will urge MPs to face the damage caused by Brexit and embrace closer ties with the EU to boost economic growth and tackle illegal immigration. The timing puts it ahead of the upcoming UK-EU summit.
Burnham will argue that Britain cannot afford to turn its back on cooperation with Europe and that the status quo is no longer good enough. He wants a calm, clear-eyed assessment from MPs across the Commons.
A No 10 source said some politicians don't want to accept that Brexit "has not delivered what they once promised." Burnham is expected to argue that most of the public would want the government to seize the chance if closer cooperation could strengthen immigration controls and revive the economy.
The fight is already heated. Senior Conservatives vow to reverse Labour's moves toward closer EU ties, including a proposed agreement to ease post-Brexit barriers on food and agricultural trade. Businesses warn that abandoning such arrangements could prolong costs and uncertainty.
That same day, MPs will debate a Westminster Hall petition, signed by more than 111,000 people, calling for Britain to rejoin the EU.